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Crystal structure of the GINS complex and functional insights into its role in DNA replication

The GINS complex, which contains the four subunits Sld5, Psf1, Psf2, and Psf3, is essential for both the initiation and progression of DNA replication in eukaryotes. GINS associates with the MCM2-7 complex and Cdc45 to activate the eukaryotic minichromosome maintenance helicase. It also appears to i...

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Detalhes bibliográficos
Main Authors: Chang, Y. Paul, Wang, Ganggang, Bermudez, Vladimir, Hurwitz, Jerard, Chen, Xiaojiang S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937527/
https://ncbi.nlm.nih.gov/pubmed/17652513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705558104
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