Moritella Cold-Active Dihydrofolate Reductase: Are There Natural Limits to Optimization of Catalytic Efficiency at Low Temperature?

Adapting metabolic enzymes of microorganisms to low temperature environments may require a difficult compromise between velocity and affinity. We have investigated catalytic efficiency in a key metabolic enzyme (dihydrofolate reductase) of Moritella profunda sp. nov., a strictly psychrophilic bacter...

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Detalhes bibliográficos
Main Authors: Xu, Ying, Feller, Georges, Gerday, Charles, Glansdorff, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Enzymes and Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193739/
https://ncbi.nlm.nih.gov/pubmed/12949104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.18.5519-5526.2003
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