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Dihydropteridine Reductase as an Alternative to Dihydrofolate Reductase for Synthesis of Tetrahydrofolate in Thermus thermophilus

A strategy devised to isolate a gene coding for a dihydrofolate reductase from Thermus thermophilus DNA delivered only clones harboring instead a gene (the T. thermophilus dehydrogenase [DH(Tt)] gene) coding for a dihydropteridine reductase which displays considerable dihydrofolate reductase activit...

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Detalhes bibliográficos
Main Authors: Wilquet, Valérie, Van de Casteele, Mark, Gigot, Daniel, Legrain, Christianne, Glansdorff, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305743/
https://ncbi.nlm.nih.gov/pubmed/14702303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.2.351-355.2004
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