DOSE DEPENDENCE AND THERAPEUTIC WINDOW FOR THE NEUROPROTECTIVE EFFECTS OF 17β-ESTRADIOL WHEN ADMINISTERED AFTER CEREBRAL ISCHEMIA

The present study was undertaken to determine if the neuroprotective effect of 17β-estradiol (E(2)) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Adm...

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Bibliographic Details
Main Authors: Liu, Ran, Wang, Xiaofei, Liu, Qing, Yang, Shao-Hua, Simpkins, James W.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1936945/
https://ncbi.nlm.nih.gov/pubmed/17331646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2007.01.074
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