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Combination Therapy of 17β-Estradiol and Recombinant Tissue Plasminogen Activator for Experimental Ischemic Stroke

Thrombolysis with recombinant tissue plasminogen activator (rtPA) in ischemic stroke is limited by the increased risk of hemorrhage transformation due to blood-brain barrier breakdown. We determined the interaction of 17β-estradiol (E2) and rtPA on activation of plasminogen system and matrix metallo...

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Bibliografski detalji
Glavni autori: Liu, Ran, Liu, Qing, He, Shaoqing, Simpkins, James W., Yang, Shao-Hua
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835431/
https://ncbi.nlm.nih.gov/pubmed/19952306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160937
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