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Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats

1. Free radicals have been implicated in cerebral ischemia reperfusion (IR) injury. Massive production of nitric oxide and superoxide results in continuous formation of peroxynitrite even several hours after IR insult. This can produce DNA strand nicks, hydroxylation and/or nitration of cytosolic co...

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Библиографические подробности
Главные авторы: Thiyagarajan, Meenakshisundaram, Kaul, Chaman Lal, Sharma, Shyam Sundar
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2004
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575059/
https://ncbi.nlm.nih.gov/pubmed/15197101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705811
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