Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution

The Werner syndrome protein (WRN) is a caretaker of the human genome, and the Abl kinase is a regulator of the DNA damage response. Aberrant DNA repair has been linked to the development of cancer. Here, we have identified a direct binding between WRN and c-Abl in vitro via the N-terminal and centra...

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Detalhes bibliográficos
Main Authors: Cheng, Wen-Hsing, Kobbe, Cayetano von, Opresko, Patricia L., Fields, Kesha M., Ren, Jian, Kufe, Donald, Bohr, Vilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193690/
https://ncbi.nlm.nih.gov/pubmed/12944467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.18.6385-6395.2003
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