PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

PKCλ is implicated as a downstream effector of PI3K in insulin action. We show here that mice that lack PKCλ specifically in the liver (L-λKO mice), produced with the use of the Cre-loxP system, exhibit increased insulin sensitivity as well as a decreased triglyceride content and reduced expression...

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Main Authors: Matsumoto, Michihiro, Ogawa, Wataru, Akimoto, Kazunori, Inoue, Hiroshi, Miyake, Kazuaki, Furukawa, Kensuke, Hayashi, Yoshitake, Iguchi, Haruhisa, Matsuki, Yasushi, Hiramatsu, Ryuji, Shimano, Hitoshi, Yamada, Nobuhiro, Ohno, Shigeo, Kasuga, Masato, Noda, Tetsuo
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC193669/
https://ncbi.nlm.nih.gov/pubmed/12975478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318816
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