The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

Nonsense-mediated mRNA decay (NMD) is a molecular pathway of mRNA surveillance that ensures rapid degradation of mRNAs containing premature translation termination codons (PTCs) in eukaryotes. NMD has been shown to also regulate normal gene expression and thus emerged as one of the key post-transcri...

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Hlavní autoři: Viegas, Marcelo H., Gehring, Niels H., Breit, Stephen, Hentze, Matthias W., Kulozik, Andreas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1935013/
https://ncbi.nlm.nih.gov/pubmed/17586820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm461
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