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Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin B Receptor–Deficient Rats: A New Model of Severe Pulmonary Arterial Hypertension

BACKGROUND: Human pulmonary arterial hypertension (PAH) is characterized by proliferation of vascular smooth muscle and, in its more severe form, by the development of occlusive neointimal lesions. However, few animal models of pulmonary neointimal proliferation exist, thereby limiting a complete un...

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Autors principals: Ivy, D. Dunbar, McMurtry, Ivan F., Colvin, Kelley, Imamura, Masatoshi, Oka, Masahiko, Lee, Dong-Seok, Gebb, Sarah, Jones, Peter Lloyd
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934986/
https://ncbi.nlm.nih.gov/pubmed/15927975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.104.491456
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