β-d-Glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres

The unusual DNA base β-d-glucosyl-hydroxymethyluracil, called “J,” replaces ≈0.5–1% of Thy in DNA of African trypanosomes but has not been found in other organisms thus far. In Trypanosoma brucei, J is located predominantly in repetitive DNA, and its presence correlates with the silencing of telomer...

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Main Authors: van Leeuwen, Fred, Taylor, Martin C., Mondragon, Angeles, Moreau, Hervé, Gibson, Wendy, Kieft, Rudo, Borst, Piet
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1998
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC19348/
https://ncbi.nlm.nih.gov/pubmed/9482891
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