Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Recent reports have challenged the notion that retroviruses and retroviral vectors integrate randomly into the host genome. These reports pointed to a strong bias toward integration in and near gene coding regions and, for gammaretroviral vectors, around transcription start sites. Here, we report th...

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Hlavní autoři: Deichmann, Annette, Hacein-Bey-Abina, Salima, Schmidt, Manfred, Garrigue, Alexandrine, Brugman, Martijn H., Hu, Jingqiong, Glimm, Hanno, Gyapay, Gabor, Prum, Bernard, Fraser, Christopher C., Fischer, Nicolas, Schwarzwaelder, Kerstin, Siegler, Maria-Luise, de Ridder, Dick, Pike-Overzet, Karin, Howe, Steven J., Thrasher, Adrian J., Wagemaker, Gerard, Abel, Ulrich, Staal, Frank J.T., Delabesse, Eric, Villeval, Jean-Luc, Aronow, Bruce, Hue, Christophe, Prinz, Claudia, Wissler, Manuela, Klanke, Chuck, Weissenbach, Jean, Alexander, Ian, Fischer, Alain, von Kalle, Christof, Cavazzana-Calvo, Marina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934585/
https://ncbi.nlm.nih.gov/pubmed/17671652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31659
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