Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

TANK-binding kinase 1 (TBK1/NAK/T2K) and I-κB Kinase (IKK-i/IKK-ɛ) play important roles in the regulation of interferon (IFN)-inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram-negative bacteria leads to activation of...

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Main Authors: Ikeda, Fumiyo, Hecker, Christina Maria, Rozenknop, Alexis, Nordmeier, Rolf Dietrich, Rogov, Vladimir, Hofmann, Kay, Akira, Shizuo, Dötsch, Volker, Dikic, Ivan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933404/
https://ncbi.nlm.nih.gov/pubmed/17599067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601773
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