Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and Integration

Encapsidation of host restriction factor APOBEC3G (A3G) into vif-deficient human immunodeficiency virus type 1 (HIV-1) blocks virus replication at least partly by C-to-U deamination of viral minus-strand DNA, resulting in G-to-A hypermutation. A3G may also inhibit HIV-1 replication by reducing viral...

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Hlavní autoři: Mbisa, Jean L., Barr, Rebekah, Thomas, James A., Vandegraaff, Nick, Dorweiler, Irene J., Svarovskaia, Evguenia S., Brown, William L., Mansky, Louis M., Gorelick, Robert J., Harris, Reuben S., Engelman, Alan, Pathak, Vinay K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933301/
https://ncbi.nlm.nih.gov/pubmed/17428871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00272-07
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