Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine–thymine tracts

Using in vivo fidelity assays in which bacterial β-galactosidase or green fluorescent protein genes served as reporters of mutations, we have identified a murine leukemia virus (MLV) RNase H mutant (Y586F) that exhibited an increase in the retroviral mutation rate ≈5-fold in a single replication cyc...

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Библиографические подробности
Главные авторы: Zhang, Wen-Hui, Svarovskaia, Evguenia S., Barr, Rebekah, Pathak, Vinay K.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2002
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC126629/
https://ncbi.nlm.nih.gov/pubmed/12119402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152186199
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