Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and Integration

Encapsidation of host restriction factor APOBEC3G (A3G) into vif-deficient human immunodeficiency virus type 1 (HIV-1) blocks virus replication at least partly by C-to-U deamination of viral minus-strand DNA, resulting in G-to-A hypermutation. A3G may also inhibit HIV-1 replication by reducing viral...

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Detalhes bibliográficos
Main Authors: Mbisa, Jean L., Barr, Rebekah, Thomas, James A., Vandegraaff, Nick, Dorweiler, Irene J., Svarovskaia, Evguenia S., Brown, William L., Mansky, Louis M., Gorelick, Robert J., Harris, Reuben S., Engelman, Alan, Pathak, Vinay K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933301/
https://ncbi.nlm.nih.gov/pubmed/17428871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00272-07
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