Human Monoclonal Antibody AVP-21D9 to Protective Antigen Reduces Dissemination of the Bacillus anthracis Ames Strain from the Lungs in a Rabbit Model

Dutch-belted and New Zealand White rabbits were passively immunized with AVP-21D9, a human monoclonal antibody to protective antigen (PA), at the time of Bacillus anthracis spore challenge using either nasal instillation or aerosol challenge techniques. AVP-21D9 (10 mg/kg) completely protected both...

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Hlavní autoři: Peterson, Johnny W., Comer, Jason E., Baze, Wallace B., Noffsinger, David M., Wenglikowski, Autumn, Walberg, Kristin G., Hardcastle, Jason, Pawlik, Jennifer, Bush, Kathryn, Taormina, Joanna, Moen, Scott, Thomas, John, Chatuev, Bagram M., Sower, Laurie, Chopra, Ashok K., Stanberry, Lawrence R., Sawada, Ritsuko, Scholz, Wolfgang W., Sircar, Jagadish
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932953/
https://ncbi.nlm.nih.gov/pubmed/17452469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00352-07
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