Human Monoclonal Antibody AVP-21D9 to Protective Antigen Reduces Dissemination of the Bacillus anthracis Ames Strain from the Lungs in a Rabbit Model

Dutch-belted and New Zealand White rabbits were passively immunized with AVP-21D9, a human monoclonal antibody to protective antigen (PA), at the time of Bacillus anthracis spore challenge using either nasal instillation or aerosol challenge techniques. AVP-21D9 (10 mg/kg) completely protected both...

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Detalhes bibliográficos
Main Authors: Peterson, Johnny W., Comer, Jason E., Baze, Wallace B., Noffsinger, David M., Wenglikowski, Autumn, Walberg, Kristin G., Hardcastle, Jason, Pawlik, Jennifer, Bush, Kathryn, Taormina, Joanna, Moen, Scott, Thomas, John, Chatuev, Bagram M., Sower, Laurie, Chopra, Ashok K., Stanberry, Lawrence R., Sawada, Ritsuko, Scholz, Wolfgang W., Sircar, Jagadish
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932953/
https://ncbi.nlm.nih.gov/pubmed/17452469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00352-07
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