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Human Monoclonal Anti-Protective Antigen Antibody Completely Protects Rabbits and Is Synergistic with Ciprofloxacin in Protecting Mice and Guinea Pigs against Inhalation Anthrax

Prevention of inhalation anthrax requires early and extended antibiotic therapy, and therefore, alternative treatment strategies are needed. We investigated whether a human monoclonal antibody (AVP-21D9) to protective antigen (PA) would protect mice, guinea pigs, and rabbits against anthrax. Control...

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Autori principali: Peterson, Johnny W., Comer, Jason E., Noffsinger, David M., Wenglikowski, Autumn, Walberg, Kristin G., Chatuev, Bagram M., Chopra, Ashok K., Stanberry, Lawrence R., Kang, Angray S., Scholz, Wolfgang W., Sircar, Jagadish
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360364/
https://ncbi.nlm.nih.gov/pubmed/16428748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.1016-1024.2006
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