Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards Phagocytized Staphylococcus aureus by the P-Glycoprotein (MDR1) Efflux Transporter in Human THP-1 Macrophages and Madin-Darby Canine Kidney Cells

P-glycoprotein (P-gp; MDR1), a major efflux transporter, recognizes various antibiotics and is present in macrophages. We have examined its effect on the modulation of the intracellular accumulation and activity of daptomycin towards phagocytized Staphylococcus aureus (ATCC 25923) in human THP-1 mac...

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Autores principales: Lemaire, Sandrine, Van Bambeke, Françoise, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932525/
https://ncbi.nlm.nih.gov/pubmed/17548493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00090-07
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