Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards Phagocytized Staphylococcus aureus by the P-Glycoprotein (MDR1) Efflux Transporter in Human THP-1 Macrophages and Madin-Darby Canine Kidney Cells

P-glycoprotein (P-gp; MDR1), a major efflux transporter, recognizes various antibiotics and is present in macrophages. We have examined its effect on the modulation of the intracellular accumulation and activity of daptomycin towards phagocytized Staphylococcus aureus (ATCC 25923) in human THP-1 mac...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lemaire, Sandrine, Van Bambeke, Françoise, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2007
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932525/
https://ncbi.nlm.nih.gov/pubmed/17548493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00090-07
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