2-tert-Butyl-8-Quinolinamines Exhibit Potent Blood Schizontocidal Antimalarial Activity via Inhibition of Heme Crystallization

We have recently reported that the attachment of a bulky metabolically stable tert-butyl group at the C-2 position of a quinoline ring in primaquine results in a tremendous improvement in the blood schizontocidal antimalarial activity of 8-quinolinamine. Because free heme released from hemoglobin ca...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Huy, Nguyen Tien, Mizunuma, Keisuke, Kaur, Kirandeep, Nhien, Nguyen Thanh Thuy, Jain, Meenakshi, Uyen, Dinh Thanh, Harada, Shigeharu, Jain, Rahul, Kamei, Kaeko
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932521/
https://ncbi.nlm.nih.gov/pubmed/17562796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00288-07
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars