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Metabolically Stable tert-Butyl Replacement
[Image: see text] Susceptibility to metabolism is a common issue with the tert-butyl group on compounds of medicinal interest. We demonstrate an approach of removing all the fully sp(3) C–Hs from a tert-butyl group: replacing some C–Hs with C–Fs and increasing the s-character of the remaining C–Hs....
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027455/ https://ncbi.nlm.nih.gov/pubmed/24900702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400045j |
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