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Evaluation of NAD(+)-Dependent DNA Ligase of Mycobacteria as a Potential Target for Antibiotics
Mycobacteria contain genes for several DNA ligases, including ligA, which encodes a NAD(+)-dependent enzyme that has been postulated to be a target for novel antibacterial compounds. Using a homologous recombination system, direct evidence is presented that wild-type ligA cannot be deleted from the...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1932498/ https://ncbi.nlm.nih.gov/pubmed/17548501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00254-07 |
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