Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-d-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct...

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Main Authors: Steinbach, William J., Cramer, Robert A., Perfect, B. Zachary, Henn, Christina, Nielsen, Kirsten, Heitman, Joseph, Perfect, John R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932494/
https://ncbi.nlm.nih.gov/pubmed/17502415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01394-06
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