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Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy

Yersinia pestis, the bacterium that causes plague, is a potential agent of biowarfare and bioterrorism. The aminoglycoside antibiotic streptomycin is the gold standard for treatment. However, this recommendation is based on scant animal and clinical data. We used an in vitro pharmacodynamic infectio...

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Detalhes bibliográficos
Main Authors: Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Drusano, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932490/
https://ncbi.nlm.nih.gov/pubmed/17517837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00073-07
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