Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

E6 and E7 oncoproteins from high risk human papillomaviruses (HPVs) transform cells in tissue culture and induce tumors in vivo. Both E6, which inhibits p53 functions, and E7, which inhibits pRb, can also abrogate growth arrest induced by DNA-damaging agents in cultured cells. In this study, we have...

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Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Song, Shiyu, Gulliver, Gene A., Lambert, Paul F.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1998
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2290
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