Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance due primarily to genetic defects in Fas (CD95/APO-1; TNFRSF6), a cell surface receptor that regulates apoptosis and its signaling apparatus. METHODS: Fas ligand gene mutatio...

詳細記述

保存先:
書誌詳細
主要な著者: Bi, Lilia L, Pan, George, Atkinson, T Prescott, Zheng, Lixin, Dale, Janet K, Makris, Christopher, Reddy, Vishnu, McDonald, Jay M, Siegel, Richard M, Puck, Jennifer M, Lenardo, Michael J, Straus, Stephen E
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2007
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1931585/
https://ncbi.nlm.nih.gov/pubmed/17605793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-8-41
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