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A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates β-catenin but its zygotic expression is not essential for the regulation of Armadillo

Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers. To facilitate the functional study of APC we have isolated its Drosophila homolog (D-APC) by screening an expression library with an antibod...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hayashi, Shigemi, Rubinfeld, Bonnee, Souza, Brian, Polakis, Paul, Wieschaus, Eric, Levine, Arnold J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19302/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8990193/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.1.242
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