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A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates β-catenin but its zygotic expression is not essential for the regulation of Armadillo

Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers. To facilitate the functional study of APC we have isolated its Drosophila homolog (D-APC) by screening an expression library with an antibod...

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Библиографические подробности
Главные авторы: Hayashi, Shigemi, Rubinfeld, Bonnee, Souza, Brian, Polakis, Paul, Wieschaus, Eric, Levine, Arnold J.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences of the USA 1997
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC19302/
https://ncbi.nlm.nih.gov/pubmed/8990193
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