α2β1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis

BACKGROUND: Ovarian cancer is characterized by a wide-spread intra-abdominal metastases which represents a major clinical hurdle in the prognosis and management of the disease. A significant proportion of ovarian cancer cells in peritoneal ascites exist as multicellular aggregates or spheroids. We h...

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Detalhes bibliográficos
Main Authors: Shield, Kristy, Riley, Clyde, Quinn, Michael A, Rice, Gregory E, Ackland, Margaret L, Ahmed, Nuzhat
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1929068/
https://ncbi.nlm.nih.gov/pubmed/17567918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3163-6-11
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