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The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

There is growing appreciation of the importance of the mechanical properties of the tumor microenvironment on disease progression. However, the role of extracellular matrix (ECM) stiffness and cellular mechanotransduction in epithelial ovarian cancer (EOC) is largely unknown. Here, we investigated t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: McKenzie, Andrew J., Hicks, Stephanie R., Svec, Kathryn V., Naughton, Hannah, Edmunds, Zöe L., Howe, Alan K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940803/
https://ncbi.nlm.nih.gov/pubmed/29740072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25589-0
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