Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia

BACKGROUND: The Na(+), K(+), 2Cl(- )type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl(-)] and thus the magnitude and polarity of GAB...

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Autors principals: Pitcher, Mark H, Price, Theodore J, Entrena, Jose M, Cervero, Fernando
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1929059/
https://ncbi.nlm.nih.gov/pubmed/17603899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-3-17
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