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Structural and Hydration Properties of the Partially Unfolded States of the Prion Protein

Misfolding and aggregation of the prion protein (PrP) is responsible for the development of transmissible spongiform encephalopathies (TSE). To gain insights into possible aggregation-prone intermediate states, we construct the free energy surface of the C-terminal globular domain of the PrP from en...

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Detalhes bibliográficos
Main Authors: De Simone, Alfonso, Zagari, Adriana, Derreumaux, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1929054/
https://ncbi.nlm.nih.gov/pubmed/17483173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.108613
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