Activation mechanisms for the cystic fibrosis transmembrane conductance regulator protein involve direct binding of cAMP

The CFTR [CF (cystic fibrosis) transmembrane conductance regulator] chloride channel is activated by cyclic nucleotide-dependent phosphorylation and ATP binding, but also by non-phosphorylation-dependent mechanisms. Other CFTR functions such as regulation of exocytotic protein secretion are also act...

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Bibliographic Details
Main Authors: Pereira, Malcolm M. C., Parker, Jody, Stratford, Fiona L. L., McPherson, Margaret, Dormer, Robert L.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1925253/
https://ncbi.nlm.nih.gov/pubmed/17381427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061879
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