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Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
A series of nucleobase-modified siRNA duplexes containing “rare” nucleosides, 2-thiouridine (s(2)U), pseudouridine (Ψ), and dihydrouridine (D), were evaluated for their thermodynamic stability and gene silencing activity. The duplexes with modified units at terminal positions exhibited similar stabi...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1924902/ https://ncbi.nlm.nih.gov/pubmed/17585051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.538907 |
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