SIV-specific CD8(+) T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection

Programmed death-1 (PD-1) is a critical mediator of virus-specific CD8(+) T-cell exhaustion. Here, we examined the expression of PD-1 on simian immunodeficiency virus (SIV)-specific CD8(+) T cells and its possible involvement in regulation of cytokine production, proliferation, and survival of these...

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Autori principali: Petrovas, Constantinos, Price, David A., Mattapallil, Joseph, Ambrozak, David R., Geldmacher, Christof, Cecchinato, Valentina, Vaccari, Monica, Tryniszewska, Elzbieta, Gostick, Emma, Roederer, Mario, Douek, Daniel C., Morgan, Sara H., Davis, Simon J., Franchini, Genoveffa, Koup, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924769/
https://ncbi.nlm.nih.gov/pubmed/17440051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-069112
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