Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing breast cancers with characteristic features also observed in sporadic basal-like breast cancers. They appear as high-grade tumors with high proliferation rates and pushing borders. On the molecular level, they are neg...

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Bibliographic Details
Main Authors: Liu, Xiaoling, Holstege, Henne, van der Gulden, Hanneke, Treur-Mulder, Marcelle, Zevenhoven, John, Velds, Arno, Kerkhoven, Ron M., van Vliet, Martin H., Wessels, Lodewyk F. A., Peterse, Johannes L., Berns, Anton, Jonkers, Jos
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924557/
https://ncbi.nlm.nih.gov/pubmed/17626182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702969104
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