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The molecular chaperone hsp40 regulates the activity of P58(IPK), the cellular inhibitor of PKR

The interferon-induced double-stranded RNA-activated protein kinase, PKR, likely contributes to both the antiviral and the antiproliferative effects of interferon. We previously found that influenza virus avoids the translational inhibitory effects of activated PKR by activating a cellular inhibitor...

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Autori principali: Melville, Mark W., Hansen, William J., Freeman, Brian C., Welch, William J., Katze, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC19244/
https://ncbi.nlm.nih.gov/pubmed/8990167
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