Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase.
The role of Ser-235 in the catalytic mechanism of the TEM-1 beta-lactamase has been explored by the study of a mutant enzyme in which Ser-235 has been substituted by alanine (Ala-235 mutant enzyme). A comparative kinetic analysis of both the wild-type and the Ala-235 TEM-1 enzymes revealed little ef...
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| Publicado no: | Antimicrob Agents Chemother |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192405/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8285630/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.11.2438 |
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