Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase.

The role of Ser-235 in the catalytic mechanism of the TEM-1 beta-lactamase has been explored by the study of a mutant enzyme in which Ser-235 has been substituted by alanine (Ala-235 mutant enzyme). A comparative kinetic analysis of both the wild-type and the Ala-235 TEM-1 enzymes revealed little ef...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Imtiaz, U, Manavathu, E K, Lerner, S A, Mobashery, S
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1993
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192405/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8285630/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.11.2438
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