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Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C.

We report that protein 2C, the putative nucleoside triphosphatase/helicase protein of poliovirus, is required for the initiation of negative-strand RNA synthesis. Preinitiation RNA replication complexes formed upon the translation of poliovirion RNA in HeLa S10 extracts containing 2 mM guanidine HCI...

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Udgivet i:J Virol
Principais autores: Barton, D J, Flanegan, J B
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192311/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343205/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8482-8489.1997
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