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Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.

Alteration of the natural tropism of adenovirus (Ad) will permit gene transfer into specific cell types and thereby greatly broaden the scope of target diseases that can be treated by using Ad. We have constructed two Ad vectors which contain modifications to the Ad fiber coat protein that redirect...

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Published in:J Virol
Main Authors: Wickham, T J, Tzeng, E, Shears, L L, Roelvink, P W, Li, Y, Lee, G M, Brough, D E, Lizonova, A, Kovesdi, I
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1997
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192279/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343173/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8221-8229.1997
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