Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside revers...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Pelemans, H, Esnouf, R, Dunkler, A, Parniak, M A, Vandamme, A M, Karlsson, A, De Clercq, E, Kleim, J P, Balzarini, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343170/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8195-8203.1997
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