Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside revers...

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Main Authors: Pelemans, H, Esnouf, R, Dunkler, A, Parniak, M A, Vandamme, A M, Karlsson, A, De Clercq, E, Kleim, J P, Balzarini, J
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC192276/
https://ncbi.nlm.nih.gov/pubmed/9343170
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