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Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells.

Abelson murine leukemia virus transforms pre-B cells in vitro and induces rapid-onset pre-B-cell lymphoma in vivo. Expression of an active v-Abl protein tyrosine kinase is required for the oncogenic functions of the virus. Despite the strong growth-stimulatory signal provided by v-Abl, the virus-ind...

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Bibliografiske detaljer
Udgivet i:J Virol
Principais autores: Thome, K C, Radfar, A, Rosenberg, N
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192271/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343165/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8149-8156.1997
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