Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells.

Abelson murine leukemia virus transforms pre-B cells in vitro and induces rapid-onset pre-B-cell lymphoma in vivo. Expression of an active v-Abl protein tyrosine kinase is required for the oncogenic functions of the virus. Despite the strong growth-stimulatory signal provided by v-Abl, the virus-ind...

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Bibliografiska uppgifter
Huvudupphovsmän: Thome, K C, Radfar, A, Rosenberg, N
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1997
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC192271/
https://ncbi.nlm.nih.gov/pubmed/9343165
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