Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.

We have developed a system for site-specific DNA integration in human cells, mediated by the adeno-associated virus (AAV) Rep proteins. In its normal lysogenic cycle, AAV integrates at a site on human chromosome 19 termed AAVS1. We describe a rapid PCR assay for the detection of integration events a...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Surosky, R T, Urabe, M, Godwin, S G, McQuiston, S A, Kurtzman, G J, Ozawa, K, Natsoulis, G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192153/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9311886/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.10.7951-7959.1997
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