Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.

We have developed a system for site-specific DNA integration in human cells, mediated by the adeno-associated virus (AAV) Rep proteins. In its normal lysogenic cycle, AAV integrates at a site on human chromosome 19 termed AAVS1. We describe a rapid PCR assay for the detection of integration events a...

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Hauptverfasser: Surosky, R T, Urabe, M, Godwin, S G, McQuiston, S A, Kurtzman, G J, Ozawa, K, Natsoulis, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC192153/
https://ncbi.nlm.nih.gov/pubmed/9311886
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