Targeted adenovirus-mediated gene delivery to T cells via CD3.

T cells are primary targets in numerous gene therapy protocols. However, the use of subgroup C adenovirus serotype 2 or 5 (Ad2 or Ad5) as a vector to transduce T cells is limited by its poor transduction efficiency for these cells. In this report we show that poor T-cell transduction results from th...

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Bibliografiske detaljer
Main Authors: Wickham, T J, Lee, G M, Titus, J A, Sconocchia, G, Bakács, T, Kovesdi, I, Segal, D M
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC192116/
https://ncbi.nlm.nih.gov/pubmed/9311849
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