Molecular cloning and expression of the human Δ7-sterol reductase

Inhibitors of the last steps of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development. Their molecular target is the Δ7-sterol reductase (EC 1.3.1.21), suspected to be defective in the Smith–Lemli–Opitz syndrome, a frequent inborn disorder of sterol metabolism. Molecu...

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Main Authors: Moebius, Fabian F., Fitzky, Barbara U., Lee, Joon No, Paik, Young-Ki, Glossmann, Hartmut
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC19210/
https://ncbi.nlm.nih.gov/pubmed/9465114
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