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High affinity of sigma(1)-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C(8)–C(7) isomerase
1. The sigma-drug binding site of guinea-pig liver is carried by a protein which shares significant amino acid sequence similarities with the yeast sterol C(8)–C(7) isomerase (ERG2 protein). Pharmacologically - but not structurally - the sigma(1)-site is also related to the emopamil binding protein,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1997
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564641/ https://ncbi.nlm.nih.gov/pubmed/9146879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701079 |
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